TH2-ASSOCIATED ALTERNATIVE KUPFFER CELL ACTIVATION PROMOTES LIVER FIBROSIS WITHOUT INDUCING LOCAL INFLAMMATION

Th2-Associated Alternative Kupffer Cell Activation Promotes Liver Fibrosis without Inducing Local Inflammation

Cirrhosis is the final outcome of liver fibrosis.Kupffer cell-mediated hepatic inflammation is considered to aggravate liver injury and fibrosis.Alternatively-activated macrophages are able to control chronic inflammatory events and trigger wound healing processes.Nevertheless, the role of alternative Kupffer cell activation in liver harm is largel

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Role of Coffee Caffeine and Chlorogenic Acids Adsorption to Polysaccharides with Impact on Brew Immunomodulation Effects

Coffee brews have High Molecular Weight (HMW) compounds with described immunostimulatory activity, namely polysaccharides and melanoidins.Melanoidins are formed during roasting and are modified during brews technological processing.In addition, brews have Low Molecular Weight (LMW) compounds, namely free chlorogenic acids and caffeine, with well-kn

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Many-body recombination in photoexcited insulating cuprates

We study the Merchandise pump-probe response of three insulating cuprates and develop a model for its recombination kinetics.The dependence on time, fluence, and both pump and probe photon energies implies many-body recombination on femtosecond timescales, characterized by anomalously large trapping and Auger coefficients.The fluence dependence fol

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